abstract：:Programmed cell death (PCD) is the regulated removal of cells within an organism and plays a fundamental role in growth and development in nearly all eukaryotes. In animals, the model organism Caenorhabditis elegans (C. elegans) has aided in elucidating many of the pathways involved in the cell death process. Various ...

journal_title：European journal of cell biology

authors： Lord CE,Gunawardena AH

更新日期：2012-08-01 00:00:00

abstract：:NAC (nascent polypeptide associated complex) is a heterodimer consisting of an α and a β subunit. skNAC (skeletal and heart muscle-specific form of αNAC) is a variant of αNAC, which is induced in muscle differentiation and regeneration. We show here that skNAC expression is regulated by p38 MAPK, which plays a crucial...

journal_title：European journal of cell biology

authors： Berger F,Berkholz J,Breustedt T,Ploen D,Munz B

更新日期：2012-02-01 00:00:00

abstract：:The rabies virus (RV) phosphoprotein P is a multifunctional protein involved in viral RNA synthesis and in counteracting host innate immune responses. We have previously shown that RV P gene expression levels can be regulated by using picornavirus internal ribosome entry site (IRES) elements. Here we exploited a parti...

journal_title：European journal of cell biology

authors： Marschalek A,Drechsel L,Conzelmann KK

更新日期：2012-01-01 00:00:00

abstract：:Adoptive T cell therapy is the transfer of T cells to a patient in order to combat disease. This procedure is mainly being used but not limited to the treatment of viral infections and malignancies including virus-associated tumors. Depending on the clinical context, the T cell donor may be the same patient or another...

journal_title：European journal of cell biology

authors： Moosmann A,Hammerschmidt W,Kolb HJ

更新日期：2012-01-01 00:00:00

abstract：:Here, we report the establishment of a permanent skin cell culture from rainbow trout (Oncorhynchus mykiss). The cells of the fish skin cell culture could be propagated over 60 passages so far. Furthermore, we show for the first time that it is possible to integrate freshly harvested rainbow trout scales into this new...

journal_title：European journal of cell biology

authors： Rakers S,Klinger M,Kruse C,Gebert M

更新日期：2011-12-01 00:00:00

abstract：:In solid body tissues, environmental biomechanics is indispensable for tissue homeostasis. While characteristics of homeostasis include morphogenesis, proliferation and differentiation, the influences through biomechanics in corneal keratinocytes are poorly understood. Here we show for the first time that corneal kera...

journal_title：European journal of cell biology

authors： Eberwein P,Steinberg T,Schulz S,Zimmermann D,Accardi R,Beck D,Reinhard T,Tomakidi P

更新日期：2011-12-01 00:00:00

abstract：:Centromeres support the assembly of the kinetochore on every chromosome and are therefore essential for the proper segregation of sister chromatids during cell division. Centromere identity is regulated epigenetically through the presence of the histone H3 variant CENP-A. CENP-A regulation and incorporation specifical...

journal_title：European journal of cell biology

authors： Pauleau AL,Erhardt S

更新日期：2011-10-01 00:00:00

abstract：:The milk yeast Kluyveromyces lactis is an alternative model yeast to the well established Saccharomyces cerevisiae. The cell wall of these fungi consists of polysaccharides (i.e. long chains of β-1,3- and β-1,6-linked sugar chains and some chitin) and mannoproteins, both of which are continually adapted to environment...

journal_title：European journal of cell biology

authors： Backhaus K,Buchwald U,Heppeler N,Schmitz HP,Rodicio R,Heinisch JJ

更新日期：2011-09-01 00:00:00

abstract：:Despite its frequent inactivation in human breast cancers, the role of p21(Cip1) (p21) in morphological plasticity of normal mammary epithelial cells is still poorly understood. To address this question, we have investigated the consequences of p21 silencing in two-dimensional (2D) morphogenesis of untransformed human...

journal_title：European journal of cell biology

authors： Bouchet BP,Fauvet F,Grelier G,Galmarini CM,Puisieux A

更新日期：2011-08-01 00:00:00

abstract：:Previously we reported the novel observation that astrocytes ensheath the persistent hyaloid artery, both in the Nuc1 spontaneous mutant rat, and in human PFV (persistent fetal vasculature) disease (Developmental Dynamics 234:36-47, 2005). We now show that astrocytes isolated from both the optic nerve and retina of Nu...

journal_title：European journal of cell biology

authors： Zhang C,Asnaghi L,Gongora C,Patek B,Hose S,Ma B,Fard MA,Brako L,Singh K,Goldberg MF,Handa JT,Lo WK,Eberhart CG,Zigler JS Jr,Sinha D

更新日期：2011-05-01 00:00:00

abstract：:Vinculin, discovered in 1979 (Geiger, 1979), is an adapter protein with binding sites for more than 15 proteins. Biochemical and structural analyses have contributed to detailed knowledge about potential binding partners and the understanding of how their binding may be regulated. Despite all this information the mole...

journal_title：European journal of cell biology

authors： Carisey A,Ballestrem C

更新日期：2011-02-01 00:00:00

abstract：:Invadopodia are actin-rich, adhesive protrusions that extend into and remodel the extracellular matrix. They are associated with high levels of pericellular proteolysis and correlate with the invasive capacity of a variety of tumour cells. Invadopodia have, thus, been proposed to recapitulate key events of the metasta...

journal_title：European journal of cell biology

authors： Frittoli E,Palamidessi A,Disanza A,Scita G

更新日期：2011-02-01 00:00:00

abstract：:The docking complex of peroxisomal matrix protein import is composed of PEX13 and PEX14 in all species analyzed so far, whereas only yeast appears to possess an additional component, PEX17. In this report we isolated PEX14 complexes of Neurospora crassa. Among the complex constituents, one protein designated as PEX33 ...

journal_title：European journal of cell biology

authors： Managadze D,Würtz C,Wiese S,Schneider M,Girzalsky W,Meyer HE,Erdmann R,Warscheid B,Rottensteiner H

更新日期：2010-12-01 00:00:00

abstract：:RIP3 belongs to a group of recently identified proteins, classified as the ICR/RIP family whose members were described to interact with Rho proteins of plants (ROPs). Our in vivo and in vitro data demonstrate that RIP3 is a true ROP effector, interacting specifically with the active form of ROPs. We found that RIP3 ha...

journal_title：European journal of cell biology

authors： Mucha E,Hoefle C,Hückelhoven R,Berken A

更新日期：2010-12-01 00:00:00

abstract：:PinX1 was originally identified as a Pin2/TRF1-interacting protein that suppresses telomerase activity via its telomerase inhibitor domain (TID) and regulates the nucleolar localization of TRF1 in telomerase-positive cells. In addition to its telomeric localization, PinX1 can be found in the nucleoli of human cells. O...

journal_title：European journal of cell biology

authors： Wang C,Yu J,Yuan K,Lan J,Jin C,Huang H

更新日期：2010-10-01 00:00:00

abstract：:The signal transduction pathways of chondrocyte area expansion and migration under periodic mechanical stress remain a matter of debate. We explore this question by performing cell culture experiments in our self-developed periodic stress field and perfusion culture system. Under periodic mechanical stress, we find th...

journal_title：European journal of cell biology

authors： Nong L,Yin G,Ren K,Tang J,Fan W

更新日期：2010-09-01 00:00:00

abstract：:In recent decades, research on peroxisome biogenesis has been particularly boosted since the role of these organelles in metabolism became unraveled. Indeed in plants, yeasts and fungi, peroxisomes play an important role in the adaptation of metabolism during developmental processes and/or altered environmental condit...

journal_title：European journal of cell biology

authors： Galland N,Michels PA

更新日期：2010-09-01 00:00:00

abstract：:Carbonic anhydrase (CA) XII, an extracellular enzyme involved in the regulation of the microenvironment acidity and tumor malignant phenotype, was originally identified as a protein overexpressed in some types of cancers, including breast cancer. However, the cellular function and mechanism of CAXII remained unclear. ...

journal_title：European journal of cell biology

authors： Hsieh MJ,Chen KS,Chiou HL,Hsieh YS

更新日期：2010-08-01 00:00:00

abstract：:Seminal roots are initiated at the scutellar node during maize (Zea mays L.) embryo development. The maize mutant rtcs (rootless concerning crown and seminal roots) does not initiate seminal roots while its wild-type siblings form on average 2.9 seminal roots per seedling. In this study, proteome profiles of 25-day-ol...

journal_title：European journal of cell biology

authors： Muthreich N,Schützenmeister A,Schütz W,Madlung J,Krug K,Nordheim A,Piepho HP,Hochholdinger F

更新日期：2010-02-01 00:00:00

abstract：:In flowering plants, gametes are formed in specialized haploid structures, termed gametophytes. The female gametophyte is a few-celled structure that integrates such diverse functions as pollen tube attraction, sperm cell release, gamete fusion and seed initiation. These processes are realized by distinct cell types, ...

journal_title：European journal of cell biology

authors： Kägi C,Gross-Hardt R

更新日期：2010-02-01 00:00:00

abstract：:The COP9 signalosome (CSN) is an evolutionarily conserved multiprotein complex with a role in the regulation of cullin-RING type E3 ubiquitin ligases (CRLs). CSN exerts its function on E3 ligases by deconjugating the ubiquitin-related protein NEDD8 from the CRL cullin subunit. Thereby, CSN has an impact on multiple CR...

journal_title：European journal of cell biology

authors： Schwechheimer C,Isono E

更新日期：2010-02-01 00:00:00

abstract：:The inner core of lipopolysaccharide (LPS) structures in Gram-negative bacteria is considered a highly conserved region. The sugar connecting the membrane-associated lipid A moiety with the hydrophilic saccharide moiety, 3-deoxy-alpha-d-manno-oct-2-ulosonic acid (Kdo) is present in every LPS molecule investigated but ...

journal_title：European journal of cell biology

authors： Gronow S,Xia G,Brade H

更新日期：2010-01-01 00:00:00

abstract：:Staphylococcus epidermidis is of major importance in infections associated with indwelling medical devices. The tight pathogenic association is essentially linked to the species ability to form adherent biofilms on artificial surfaces. Aiming at identifying novel targets for vaccination or therapy much effort has been...

journal_title：European journal of cell biology

authors： Rohde H,Frankenberger S,Zähringer U,Mack D

更新日期：2010-01-01 00:00:00

abstract：:Storage and release of proteins from granules forms the basis of cellular functions as diverse as cell mediated cytotoxicity, neuronal communication, activation of muscle fibres, and release of hormones or digestive enzymes from endocrine and exocrine glands, such as the pancreas. Serglycin is the major intracellular ...

journal_title：European journal of cell biology

authors： Niemann CU,Cowland JB,Ralfkiaer E,Abrink M,Pejler G,Borregaard N

更新日期：2009-08-01 00:00:00

abstract：:In the mouse genome, 20 connexin genes have been detected that code for proteins of high sequence identity in the two extracellular loops, especially six conserved cysteine residues. The mouse connexin23 (Cx23) gene (Gje1) differs from all other connexin genes in vertebrates, since it codes for a protein that contains...

journal_title：European journal of cell biology

authors： Sonntag S,Söhl G,Dobrowolski R,Zhang J,Theis M,Winterhager E,Bukauskas FF,Willecke K

更新日期：2009-02-01 00:00:00

abstract：:Lamin proteins are components of metazoan cell nuclei. During evolution, two classes of lamin proteins evolved, A- and B-type lamins. B-type lamins are expressed in nearly all cell types and in all developmental stages and are thought to be indispensable for cellular survival. In contrast, A-type lamins have a more re...

journal_title：European journal of cell biology

authors： Peter A,Stick R

更新日期：2008-11-01 00:00:00

abstract：:Since various neuromuscular diseases are associated with abnormal glycosylation, it was of interest to determine whether this key post-translational modification is also altered in aged skeletal muscle. Lectins represent highly versatile carbohydrate-binding proteins that are routinely employed for the characterizatio...

journal_title：European journal of cell biology

authors： O'Connell K,Doran P,Gannon J,Ohlendieck K

更新日期：2008-10-01 00:00:00

abstract：:The sister chromatid cohesion complex of Saccharomyces cerevisiae includes chromosomal ATPases Smc1p and Smc3p, the kleisin Mcd1p/Scc1p, and Irr1p/Scc3p, the least studied component. We have created an irr1-1 mutation (F658G substitution) which is lethal in the haploid and semi-dominant in the heterozygous diploid irr...

journal_title：European journal of cell biology

authors： Cena A,Kozłowska E,Płochocka D,Grynberg M,Ishikawa T,Fronk J,Kurlandzka A

更新日期：2008-10-01 00:00:00

abstract：:Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mech...

journal_title：European journal of cell biology

authors： Wernimont SA,Cortesio CL,Simonson WT,Huttenlocher A

更新日期：2008-09-01 00:00:00

abstract：:Cell-matrix adhesions are essential for cell migration, tissue organization and differentiation, therefore playing central roles in embryonic development, remodeling and homeostasis of tissues and organs. Matrix adhesion-dependent signals cooperate with other pathways to regulate biological functions such as cell surv...

journal_title：European journal of cell biology

authors： Block MR,Badowski C,Millon-Fremillon A,Bouvard D,Bouin AP,Faurobert E,Gerber-Scokaert D,Planus E,Albiges-Rizo C

更新日期：2008-09-01 00:00:00

abstract：:Kynurenic acid (KYNA), a tryptophan metabolite in the kynurenine pathway, is protective against various insults. However, the molecular mechanism of this protective effect has not been identified. In this study, we examined the protective effects of KYNA against 1-methyl-4-phenylpyridinium (MPP(+)), the best-character...

journal_title：European journal of cell biology

authors： Lee DY,Lee KS,Lee HJ,Noh YH,Kim DH,Lee JY,Cho SH,Yoon OJ,Lee WB,Kim KY,Chung YH,Kim SS

更新日期：2008-06-01 00:00:00

abstract：:The outer dense fiber protein ODF2 is the major component of the sperm tail cytoskeleton and a critical component of the mature centriole of the centrosome. Centriole maturation involves the formation of appendages and the recruitment of ODF2/Cenexin. ODF2 and Cenexin are alternative splice variants that differ in a s...

journal_title：European journal of cell biology

authors： Hüber D,Geisler S,Monecke S,Hoyer-Fender S

更新日期：2008-03-01 00:00:00

abstract：:Embryonic stem (ES) cells are omnipotent; they can differentiate into every cell type of the body. The development of culture conditions that allow their differentiation has made it conceivable to produce large numbers of cells with lineage-specific characteristics in vitro. Here, we describe a method by which murine ...

journal_title：European journal of cell biology

authors： Haase I,Knaup R,Wartenberg M,Sauer H,Hescheler J,Mahrle G

更新日期：2007-12-01 00:00:00

abstract：:Members of the transforming growth factor beta (TGF-beta) superfamily of signaling molecules are involved in the regulation of many developmental processes that involve the interaction between mesenchymal and epithelial tissues. Smad7 is a potent inhibitor of many members of the TGF-beta family, notably TGF-beta and a...

journal_title：European journal of cell biology

authors： Klopcic B,Maass T,Meyer E,Lehr HA,Metzger D,Chambon P,Mann A,Blessing M

更新日期：2007-12-01 00:00:00

abstract：:As proposed by Hanahan and Weinberg (2000. Cell 100, 57-70) carcinogenesis requires crucial events such as (i) genomic instability, (ii) cell cycle deregulation, (iii) induction of a telomere length maintenance mechanism, and (iv) an angiogenic switch. By comparing the expression of p53, cyclin D1, p16, hTERT, and TSP...

journal_title：European journal of cell biology

authors： Burnworth B,Arendt S,Muffler S,Steinkraus V,Bröcker EB,Birek C,Hartschuh W,Jauch A,Boukamp P

更新日期：2007-12-01 00:00:00

abstract：:The murine recessive yellow (Mc1r(e)) is a loss-of-function mutation in the receptor for alpha-melanocyte-stimulating hormone, melanocortin receptor 1 (Mc1r) and produces yellow coats by inducing pheomelanin synthesis in hair follicular melanocytes. However, it is not known whether the Mc1r(e) mutation affects the pro...

journal_title：European journal of cell biology

authors： Hirobe T,Abe H,Wakamatsu K,Ito S,Kawa Y,Soma Y,Mizoguchi M

更新日期：2007-06-01 00:00:00

abstract：:Herein we report that Gts1p fused with green-fluorescent protein (GFP) is localized in the cortical actin patch besides nuclei in yeast and the cortical Gts1p changed its position together with the patch depending on the cell-cycle phase, while nuclear Gts1p accumulated predominantly in the budding phase. Whereas Gts1...

journal_title：European journal of cell biology

authors： Yaguchi S,Shen H,Tsurugi K

更新日期：2007-05-01 00:00:00

abstract：:Translin is an evolutionarily conserved approximately 27-kDa protein that binds to specific DNA and RNA sequences and has diverse cellular functions. Here, we report the cloning and characterization of the translin orthologue from the fruit fly Drosophila melanogaster. Under protein-denaturing conditions, purified Dro...

journal_title：European journal of cell biology

authors： Suseendranathan K,Sengupta K,Rikhy R,D'Souza JS,Kokkanti M,Kulkarni MG,Kamdar R,Changede R,Sinha R,Subramanian L,Singh K,Rodrigues V,Rao BJ

更新日期：2007-03-01 00:00:00

abstract：:Initiation of eukaryotic DNA replication is achieved by the sequential binding of different proteins to origins of DNA replication. Using EGFP-tagged initiator proteins and immunofluorescence techniques we found that most of the ORC and the MCM subunits are localised at centrosomes and are colocalised with the polo-li...

journal_title：European journal of cell biology

authors： Stuermer A,Hoehn K,Faul T,Auth T,Brand N,Kneissl M,Pütter V,Grummt F

更新日期：2007-01-01 00:00:00

abstract：:Rho GTPases are ubiquitously expressed across the eukaryotes where they act as molecular switches participating in the regulation of many cellular processes. We present an inventory of proteins involved in Rho-regulated signaling pathways in Dictyostelium discoideum that have been identified in the completed genome se...

journal_title：European journal of cell biology

authors： Vlahou G,Rivero F

更新日期：2006-09-01 00:00:00